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Endogenous retrovirus ERV-DC8 highly integrated in domestic cat populations is a replication-competent provirus

Year: 2024
Type: article
Abstract: Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections in vertebrate genomes and are inherited by offspring. ERVs can produce pathogenic viruses through gene mutations or recombination. ERVs in domestic cats (ERV-DCs) generate feline leukemia virus subgroup D (FeLV-D) through viral recombination. Herein, we characterized the locus ERV-DC8, on chromosome B1, as an infectious replication-competent provirus. ERV-DC8 infected several cell lines, including human cells. Transmission electron microscopy of ERV-DC8 identified the viral release as a Gammaretrovirus. ERV-DC8 was identified as the FeLV-D viral interference group, with feline copper transporter 1 as its viral receptor. Insertional polymorphism analysis showed high ERV-DC8 integration in domestic cats. This study highlights the role, pathogenicity, and evolutionary relationships between ERVs and their hosts.
DOI: 10.1016/j.bbrc.2024.150521
Authors: Didik Pramono, Yutaro Muto, Yo Shimazu, R.M.C. Deshapriya, Isaac Makundi, MaríaCruz Arnal, Daniel Fernández de Luco, Minh Ha Ngo, Ariko Miyake, Kazuo Nishigaki
Institutions: Yamaguchi University, Research Institute for Cell Design Medical Science, Yamaguchi University, University of Peradeniya, Sokoine University of Agriculture, Universidad de Zaragoza, Western University
Language: English
Subfield: Plant Science
Open Access status: hybrid
Estimated APC paid: $2,880
OpenAlex ID: W4401445567
FWCI: 0.243
Cites: 33
Cited by: 1
Related to: 10