Work

Anti-HIV Activity of Philippine Crocodile (Crocodylus mindorensis) Serum on Infected Human Mononuclear Cells

Year: 2024

Type: article

Abstract: The search for effective inhibitors of HIV-1 replication remains a critical research area of research in virology and immunology. Natural products have emerged as promising candidates for antiviral therapies. In the present study, we assessed the potential inhibitory activity of Philippine crocodile serum at both pre- and post-infection stages of the HIV-1 replication cycle. Freshly collected crocodile serum samples were used in a cell culture-based assay with peripheral blood mononuclear cells. HIV-1 reverse transcriptase activity in the treated cell culture system was assessed using colorimetric enzyme immunoassay. The crocodile serum at 0.5% and 0.25% vol/vol concentrations showed an inhibitory activity against HIV-1 replication both in pre-infection interactions (68.61 ± 1.67% and 69.95 ± 2.24%, respectively) and post-infection interactions (65.68 ± 2.93% and 69.92 ± 0.45%, respective). These findings suggest that Philippine crocodile serum may have potential as a natural inhibitor of HIV-1 replication and warrant further investigation into its therapeutic use.

Source: Acta Microbiologica Hellenica

DOI: 10.3390/amh69030017

Authors: Alfredo A. Hinay, Nelyn Mae T. Cadotdot, Marilou V. Tablizo, Aprilyn F. Francisco

Institution: University of the Immaculate Conception

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,364