Work

Targeting lysosomes by design: novel N -acridine thiosemicarbazones that enable direct detection of intracellular drug localization and overcome P-glycoprotein (Pgp)-mediated resistance

Year: 2024

Type: article

Abstract: Inclusion of the acridine moiety into the thiosemicarbazone framework of NATs facilitates their function as lysosomotropic substrates for P-glycoprotein (Pgp). This promotes lysosomal targeting and effectively overcomes Pgp-mediated drug resistance.

Source: Chemical Science

DOI: 10.1039/d4sc04339a

Authors: Busra Kaya, Henry Smith, Yanbing Chen, Mahan Gholam Azad, Tiffany M. Russell, Vera Richardson, Paul V. Bernhardt, Mahendiran Dharmasivam, Des R. Richardson

Institutions: Griffith University, The University of Sydney, The University of Queensland, Nagoya University

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Thrasher Research Fund, National Breast Cancer Foundation, Griffith University, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, Tour de Cure, Medical Research Council, Australian Research Council, National Health and Medical Research Council

Awards: G1468294473, G2337203496, Pharmaceutical Development of Innovative "Trojan Horse" Anti-Cancer Agents that Inhibit Desmoplasia by Reprogramming Signalling, To Biochemically Trick P-Glycoprotein (Pgp) to Target Resistance via Lysosomal Pgp, Novel Hormone Analogues as an Innovative Endocrinological Intervention for the Anaemia of Chronic Disease, G3094260312, Melanotransferrin: A “Missing Link” and a Novel Pharmacological Target for Treatment, Biomedical Investigations of Pharmacology and Pathology for Disease Treatment, The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide, Hormone Transport by Alpha-2-Macroglobulin: Novel Roles in Regulating Hormone Activity, Pharmacological and Pharmaceutical Development of Novel Drugs for Multiple Major Disease States, G6657081448

OpenAlex ID: W4401611491

FWCI: 3.252

Cites: 84

Cited by: 19

Related to: 10