Get started
Work

Effects of prenatal small-quantity lipid-based nutrient supplements on pregnancy, birth, and infant outcomes: a systematic review and meta-analysis of individual participant data from randomized controlled trials in low- and middle-income countries

Year: 2024
Type: review
Abstract: BACKGROUND: Undernutrition during pregnancy increases the risk of giving birth to a small vulnerable newborn. Small-quantity lipid-based nutrient supplements (SQ-LNSs) contain both macro- and micronutrients and can help prevent multiple nutritional deficiencies. OBJECTIVES: We examined the effects of SQ-LNSs provided during pregnancy compared with 1) iron and folic acid or standard of care (IFA/SOC) or 2) multiple micronutrient supplements (MMSs) and identified characteristics that modified the estimates of effects of SQ-LNSs on birth outcomes. METHODS: We conducted a 2-stage meta-analysis of individual participant data from 4 randomized controlled trials of SQ-LNSs provided during pregnancy (n = 5273). We generated study-specific and subgroup estimates of SQ-LNS compared with IFA/SOC or MMS and pooled the estimates. In sensitivity analyses, we examined whether the results differed depending on methods for gestational age dating, birth anthropometry, or study design. RESULTS: , inflammation, malaria, or household food insecurity. Effect estimates for SQ-LNSs compared with MMSs were greater for certain outcomes among female infants, first-born infants, and mothers <25 y. CONCLUSIONS: SQ-LNSs had positive impacts on multiple outcomes compared to IFA/SOC, but further research directly comparing SQ-LNSs and MMSs is needed. Targeting SQ-LNSs to vulnerable subgroups may be worth considering. CLINICAL TRIAL REGISTRY: This study was registered at PROSPERO as CRD42021283391.
DOI: 10.1016/j.ajcnut.2024.08.008
Authors: Kathryn G Dewey, K Ryan Wessells, Charles D Arnold, Seth Adu-Afarwuah, Benjamin F Arnold, Per Ashorn, Ulla Ashorn, Ana Garcés, Lieven Huybregts, Nancy F Krebs, Anna Lartey, Jef L Leroy, Kenneth Maleta, Susana L Matias, Sophie E Moore, Malay K Mridha, Harriet Okronipa, Christine P Stewart
Institutions: University of California, Davis, University of Ghana, University of California, San Francisco, Tampere University, Tampere University Hospital, University of Tampere, Jhpiego, International Food Policy Research Institute, University of Colorado Anschutz, University of Colorado Denver, Kamuzu University of Health Sciences, University of California, Berkeley, King's College London, London School of Hygiene & Tropical Medicine, MRC Unit the Gambia, BRAC, Oklahoma State University
Language: English
Field: Nursing
Open Access status: hybrid
Estimated APC paid: $5,100
OpenAlex ID: W4401629768
FWCI: 2.006
Cites: 51
Cited by: 20
Related to: 10