Year: 2024
Type: article
Abstract: The cytoskeleton is essential for mechanical signal transduction and autophagy. However, few studies have directly demonstrated the contribution of the cytoskeleton to mechanical stress-induced autophagy. We explored the role of the cytoskeleton in response to compressive force-induced autophagy in human cell lines. Inhibition and activation of cytoskeletal polymerization using small chemical molecules revealed that cytoskeletal microfilaments are required for changes in the number of autophagosomes, whereas microtubules play an auxiliary role in mechanical stress-induced autophagy. The intrinsic mechanical properties and special intracellular distribution of microfilaments may account for a large proportion of compression-induced autophagy. Our experimental data support that microfilaments are core components of mechanotransduction signals.
Source: Cell Proliferation
DOI: 10.1111/cpr.13728
Institutions: Wenzhou Medical University, Chinese Academy of Sciences, Shanghai Institute of Applied Physics, University of Chinese Academy of Sciences, Shanghai Advanced Research Institute, Shanghai Synchrotron Radiation Facility, Shanghai Jiao Tong University, Shanghai Normal University, Shanghai University, Ningbo University
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,680
OpenAlex ID: W4401711599