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Antitumor effects of a Sb-rich polyoxometalate on non-small-cell lung cancer by inducing ferroptosis and apoptosis

Year: 2024
Type: article
Abstract: , respectively. Transcriptomic analysis indicated the alteration of ferroptosis and apoptosis signaling pathways in POM-treated NSCLC cells. Subsequent experimentation confirmed the induction of ferroptosis, evidenced by 5.6-fold elevated lipid peroxide levels with treatment of 5 μM POM-1, alongside increased expression of ferroptosis-associated proteins. Additionally, the apoptosis induced by POM-1 was also validated by the 19.67% and 30.1% increase in apoptotic cells in H1299 and A549 cells treated with 5 μM POM-1, respectively, as well as the upregulated activation of caspase-3. In summary, this study reveals, for the first time, ferroptosis as the antitumor mechanism of Sb-rich POM, and that synergism with ferroptosis and apoptosis is a highly potent antitumor strategy for POM-based antitumor therapy.
DOI: 10.1039/d4sc03856h
Authors: Jie-Wei Lin, Yang Zhou, Hui-Ping Xiao, Lei-Lei Wu, Peng-Cheng Li, Ming-Dong Huang, Dong Xie, Peng Xu, Xin-Xiong Li, Zhi-Xin Li
Institutions: Tongji University, Shanghai Pulmonary Hospital, Fuzhou University, Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Fudan University, Fudan University Shanghai Cancer Center
Language: English
Open Access status: diamond
OpenAlex ID: W4401926499
FWCI: 0.875
Cites: 49
Cited by: 10
Related to: 10