Work

High altitude polycythemia and its maladaptive mechanisms: an updated review

Year: 2024

Type: review

Abstract: High altitude polycythemia is a maladaptation of highlanders exposed to hypoxic environment, leading to high blood viscosity and severe cardiorespiratory dysfunction. Prolonged hypoxia causes respiratory depression and severe hypoxemia, and further mediates changes in genetic and molecular mechanisms that regulate erythropoiesis and apoptosis, ultimately resulting in excessive erythrocytosis (EE). This updated review investigated the maladaptive mechanisms of EE, including respiratory chemoreceptor passivation, sleep-related breathing disorders, sex hormones, iron metabolism, and hypoxia-related factors and pathways.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2024.1448654

Authors: Shijie Tang, Wenwen Zhou, Ling Chen, Hui Yan, Lei Chen, Fengming Luo

Institutions: Sichuan University, West China Medical Center of Sichuan University, West China Hospital of Sichuan University

Language: English

Topic: High Altitude and Hypoxia

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295