Bacteroides ovatus alleviates dysbiotic microbiota-induced graft-versus-host disease
Year: 2024
Type: article
Abstract: Acute gastrointestinal intestinal GVHD (aGI-GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation, and the intestinal microbiota is known to impact on its severity. However, an association between treatment response of aGI-GVHD and the intestinal microbiota has not been well-studied. In a cohort of patients with aGI-GVHD (n=37), we found that non-response to standard therapy with corticosteroids was associated with prior treatment with carbapenem antibiotics and loss of Bacteroides ovatus from the microbiome. In a mouse model of carbapenem-aggravated GVHD, introducing Bacteroides ovatus reduced severity of GVHD and improved survival. Bacteroides ovatus reduced degradation of colonic mucus by another intestinal commensal, Bacteroides thetaiotaomicron, via its ability to metabolize dietary polysaccharides into monosaccharides, which then inhibit mucus degradation by Bacteroides thetaiotaomicron and reduce GVHD-related mortality.
Source: Cell Host & Microbe
Authors: Eiko Hayase, Tomo Hayase, Akash Mukherjee, Stuart C. Stinson, Mohamed A. Jamal, Miriam R. Ortega, Christopher A. Sanchez, Saira S. Ahmed, Jennifer L. Karmouch, Chia-Chi Chang, Ivonne I. Flores, Lauren K. McDaniel, Alexandria N. Brown, Rawan K. El-Himri, Valerie A. Chapa, Lin Tan, Bao Q. Tran, Yao Xiao, Christopher Fan, Dung Pham, Taylor M. Halsey, Yimei Jin, Wen-Bin Tsai, Rishika Prasad, Israel K. Glover, Altai Enkhbayar, Aqsa Mohammed, Maren Schmiester, Katherine Y. King, Robert A. Britton, Pavan Reddy, Matthew C. Wong, Nadim J. Ajami, Jennifer A. Wargo, Samuel Shelburne, Pablo C. Okhuysen, Chen Liu, Stephanie W. Fowler, Margaret E. Conner, Zoe Katsamakis, Natalie Smith, Marina Burgos da Silva, Doris M. Ponce, Jonathan U. Peled, Marcel R.M. van den Brink, Christine B. Peterson, Gabriela Rondon, Jeffrey J. Molldrem, Richard E. Champlin, Elizabeth J. Shpall, Philip L. Lorenzi, Rohtesh S. Mehta, Eric C. Martens, Amin M. Alousi, Robert R. Jenq
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funders: National Marrow Donor Program, V Foundation for Cancer Research, Be The Match Foundation, Cancer Prevention and Research Institute of Texas, Memorial Sloan-Kettering Cancer Center, Society of Memorial Sloan Kettering, American Society for Transplantation and Cellular Therapy, Hokkaido University, DKMS Foundation, National Institutes of Health, University of Texas MD Anderson Cancer Center, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G1693704207, G1766785608, G2051006376, G2167207767, G2554374655, G2556444078, G289723095, G293715275, G3638547856, G4222884455, Mucus-degrading intestinal bacteria and toxicities of hematopoietic cell transplantation, Protecting colonic mucus to mitigate acute intestinal graft-versus-host disease, Microbiota mechanisms and biomarkers in GVHD, G6906829653, G8280766540, G8473269974, G9000155989, G9000174336, Cancer Center Support Grant, Cancer Center Support Grant, Texas Medical Center Digestive Diseases Center, Impact of Infection and Inflammation on Primitive Hematopoiesis, New data science approaches to visualize and understand the impact of the microbiome on risk of graft-versus-host disease
OpenAlex ID: W4401993205