Clinical Outcome of Vitamin D Supplementation in Moderate and Severe COVID-19 Patients: A Randomized Clinical Trial
Year: 2024
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: The COVID-19 pandemic has posed a major global health challenge, especially for individuals with underlying health issues. This study aimed to assess the clinical outcomes of vitamin D supplementation in patients with moderate to severe COVID-19 in a tertiary care hospital through a randomized clinical trial. Sixty-two SARS-CoV-2 positive patients were enrolled and divided into intervention (vitamin D supplementation) and control groups. Key findings include: The intervention group showed a significant reduction in the need for supplemental oxygen therapy by day 14. Vitamin D supplementation had a steroid-sparing effect, with fewer patients in the intervention group needing steroids compared to the control group. Patients in the intervention group experienced better clinical outcomes, with reduced ICU transfers and shorter hospital stays. A significant decrease in inflammatory markers, specifically ferritin and D-dimer levels, was observed in the intervention group by day 14. Despite these improvements, no significant correlation was found between vitamin D supplementation and overall mortality rates. The study concluded that vitamin D supplementation could be a beneficial adjunctive treatment for managing moderate to severe COVID-19, potentially improving clinical outcomes and reducing healthcare burdens. However, further research with larger sample sizes is needed to validate these findings and establish comprehensive guidelines for vitamin D use in COVID-19 treatment protocols. This abstract provides a concise summary of the study, outlining the purpose, methodology, key findings, and conclusions, reflecting the content of the research accurately.
Source: Academia Journal of Medicine
Authors: Dr. Sanket Agrawal, Dr. Sushant Meshram, Dr. Shruti Agrawal, Dr. Kamlesh Taori, Dr. Shubham Biyani
Language: English
Topic: Vitamin D Research Studies
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4402113709