Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background Research on calcium intake as well as variants in the calcium sensor receptor (CaSR) gene and their interaction in relation to CRC survival is still limited. Methods Data from 18,952 CRC patients, were included. Associations between primarily pre-diagnostic dietary (n = 13.085), supplemental (n = 11,837), total calcium intake (n = 5970) as well as 325 single nucleotide polymorphisms (SNPs) of the CaSR gene (n = 15,734) in relation to CRC-specific and all-cause mortality were assessed using Cox proportional hazard models. Also interactions between calcium intake and variants in the CaSR gene were assessed. Results During a median follow-up of 4.8 years (IQR 2.4–8.4), 6801 deaths occurred, of which 4194 related to CRC. For all-cause mortality, no associations were observed for the highest compared to the lowest sex- and study-specific quartile of dietary (HR 1.00, 95%CI 0.92–1.09), supplemental (HR 0.97, 95%CI 0.89–1.06) and total calcium intake (HR 0.99, 95%CI 0.88–1.11). No associations with CRC-specific mortality were observed either. Interactions were observed between supplemental calcium intake and several SNPs of the CaSR gene. Conclusion Calcium intake was not associated with all-cause or CRC-specific mortality in CRC patients. The association between supplemental calcium intake and all-cause and CRC-specific mortality may be modified by genetic variants in the CaSR gene.
Source: BJC Reports
Authors: Evertine Wesselink, William Gauderman, Sonja I. Berndt, Hermann Brenner, Daniel D. Buchanan, Peter T. Campbell, Andrew T. Chan, Jenny Chang-Claude, Michelle Cotterchoi, Marc J. Gunter, Michael Hoffmeister, Amit D. Joshi, Christina C. Newton, Rish K. Pai, Andrew J. Pellatt, Amanda I. Phipps, Mingyang Song, Caroline Y. Um, Bethany van Guelpen, Emily White, Ulrike Peters, Fränzel J. B. van Duijnhoven
Institutions: Wageningen University & Research, University of Southern California, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, German Cancer Research Center, National Center for Tumor Diseases, Deutsches Konsortium für Translationale Krebsforschung, The Royal Melbourne Hospital, The University of Melbourne, Albert Einstein College of Medicine, Broad Institute, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, University Cancer Center Hamburg, University of Toronto, Cancer Care Ontario, Centre international de recherche sur le cancer, Imperial College London, American Cancer Society, Mayo Clinic in Arizona, The University of Texas MD Anderson Cancer Center, University of Washington, Fred Hutch Cancer Center, Umeå University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,590
Funders: U.S. Department of Health and Human Services, American Cancer Society, World Health Organization, Brigham and Women's Hospital, Fred Hutchinson Cancer Research Center, Emory University, Division of Cancer Prevention, National Cancer Institute, Johns Hopkins University, Harvard T.H. Chan School of Public Health, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Cancer Research UK, National Institute for Health and Care Research, Imperial College London, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Knut och Alice Wallenbergs Stiftelse, Ligue Contre le Cancer, Vetenskapsrådet, Umeå Universitet, Cancer Research Foundation in Northern Sweden, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, National Institutes of Health, Centers for Disease Control and Prevention, Medical Research Council, World Cancer Research Fund, National Health and Medical Research Council, Cancer Council Victoria, Instituto de Salud Carlos III, NIHR Imperial Biomedical Research Centre, School of Public Health, Imperial College London, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Cancer Institute, Office of Research Infrastructure Programs, National Institutes of Health
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OpenAlex ID: W4402146244