Gut microbiota: Implications in pathogenesis and therapy to cardiovascular disease (Review)
Year: 2024
Type: review
Abstract: The gut microbiota refers to the diverse bacterial community residing in the gastrointestinal tract. Recent data indicate a strong correlation between alterations in the gut microbiota composition and the onset of various diseases, notably cardiovascular disorders. Evidence suggests the gut-cardiovascular axis signaling molecules released by the gut microbiota play a pivotal role in regulation. This review systematically delineates the association between dysbiosis of the gut microbiota and prevalent cardiovascular diseases, including atherosclerosis, hypertension, myocardial infarction and heart failure. Furthermore, it provides an overview of the putative pathogenic mechanisms by which dysbiosis in the gut microbiota contributes to the progression of cardiovascular ailments. The potential modulation of gut microbiota as a preventive strategy against cardiovascular diseases through dietary interventions, antibiotic therapies and probiotic supplementation is also explored and discussed within the present study.
Authors: Li Lin, Shaowei Xiang, Yuan Chen, Yan Liu, Dingwen Shen, Xiaoping Yu, Zhe Wu, Yanling Sun, Kequan Chen, Jia Luo, Guilai Wei, Zhiguo Wang, Zhifeng Ning
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4402442032