The role of signaling pathways mediated by the GPCRs CysLTR1/2 in melanocyte proliferation and senescence
Year: 2024
Type: review
Abstract: In contrast with sun exposure-induced melanoma, rarer melanocytic tumors and neoplasms with low mutational burden present opportunities to study isolated signaling mechanisms. These include uveal melanoma and blue nevi, which are often driven by mutations within the G protein-coupled signaling cascade downstream of cysteinyl leukotriene receptor 2. Here, we review how the same mutations within this pathway drive the growth of melanocytes in one tissue but can inhibit the growth of those in another, exemplifying the role of the tissue environment in the delicate balance between uncontrolled cell growth and senescence.
Source: Science Signaling
Language: English
Topic: Melanoma and MAPK Pathways
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Tri-Institutional PhD Program in Chemical Biology, Understanding the roles of TMPRSS2 and ERG in pathogenesis of prostate cancer., Cancer Center Support Grant, Tri-institutional PhD Program in Chemical Biology, SPORE in Prostate Cancer, Role of ETS factors in specifying prostate luminal cell identity and androgen receptor dependence
OpenAlex ID: W4402556876