Year: 2024
Type: article
Abstract: Introduction: Over the years, metronidazole floating microspheres have been used to prolong the gastric residence time after oral administration and in the treatment of certain diseases such as peptic ulcer and other gastrointestinal infections.Aim: Development and in vitro evaluation of metronidazole floating microspheres in the treatment of gastrointestinal infections.Methods: The microspheres were formulated using inotropic gelation method.A homogenous polymer solution was prepared by dissolving sodium alginate (1 g) and the polymers (1 g each) in 32 ml of distilled water.The drug was added to the polymer solution and stirred continuously to form a viscous dispersion.A 10 % w/v quantity of Cacl2 solution was prepared and used as a cross-linking agent.The dispersion was added drop wise for 15 minutes for the curing reaction to take place.The spheres obtained were then washed and dried at 45 oC for 12 hours.Results: The percentage yield of the formulations ranged from 72.50 % ± 1.77 to 84.50 % ± 3.18.The angle of repose ranged from 3.25o ± 0.04 to 6.85o ± 0.32, while the bulk density ranged from 0.40 g/ml ± 0.07 to 0.64 g/ml ± 0.01.The Carr's index ranged from 13.04 % ± 0.04 to 15.04 % ± 0.01.The swelling index ranged from 62.00 % ± 0.71 to 83.50 % ± 0.35 without a significant difference (p < 0.05).The in vitro drug release showed that formulation F-5 gave the least release at 28.75 % ± 0.81 after 4 hours. Conclusion:The formulation F-5 was chosen as the most appropriate formulation from all tested and was optimized.
DOI: 10.30654/mjps.10032
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4403137125