Year: 2024
Type: article
Abstract: Inflammation is a crucial response to injury and infection, but when it becomes chronic, it can contribute to various diseases such as arthritis, cardiovascular issues, and neurodegenerative disorders.Traditional anti-inflammatory drugs like NSAIDs and corticosteroids effectively alleviate symptoms but often come with significant side effects, including gastrointestinal, cardiovascular, and renal complications.This has sparked growing interest in natural anti-inflammatory agents derived from plants, known for their potential to mitigate these adverse effects.Bioactive compounds found in plants, including flavonoids, terpenoids, and alkaloids, have demonstrated promising anti-inflammatory properties.Arctigenin, a bioactive lignan present in several plants, has attracted attention due to its potent anti-inflammatory effects.Arctigenin works by influencing critical inflammatory pathways, such as inhibiting NF-κB activation, reducing pro-inflammatory cytokines, and counteracting oxidative stress.Its mechanism involves suppressing inflammatory mediators and enzymes like COX-2 and iNOS.Additionally, arctigenin blocks the MAPK and PI3K/ Akt signaling pathways, underscoring its potential therapeutic value.In addition, arctigenin shows promise as a candidate for drug development due to its multifaceted anti-inflammatory mechanisms and limited side effects.However, extensive follow-up studies, including clinical trials and pharmacokinetic evaluations, are necessary to fully understand its therapeutic potential, safety profile, and effectiveness in human use.
Authors: Acharya Balkrishna, Maneesha Rana, Shalini Mishra, Satyendra Kumar Rajput, Muralikrishnan Dhanasekaran, Rajesh Kumar Mishra, Vedpriya Arya, Shalini Singh
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
Award: G8431079771
OpenAlex ID: W4403158335