Effect of Ruta chalepensis Oil Extract against Hepatotoxicity of Potassium Bromate on Liver Weight and Some Biochemical Parameters of Male Rats
Year: 2024
Type: article
Abstract: Potassium bromate (KBrO3) is widely used as improving additive for bread making. Ruta chalepensis (R. chalepensis) is used throughout the world as a herbal remedy for various illnesses. The present study aimed to investigate the possible protective and curative effects of R. chalepensis oil extract against KBrO3 toxicity on male rats. Fifty male albino rats divided into five groups. Group (1): served as a control group. Group (2): administered R. chalepensis. Group (3): received KBrO3. Group (4): protective group. Group (5): therapeutic group. After 2nd and 4th weeks, the determination of liver weights and relative liver weight were calculated, also, the resultant sera were collected for biochemical assays including ASAT, ALP, total proteins, albumin in the blood serum. The results of the present study showed after 4 weeks decrease in liver weight in R. chalepensis, KBrO3 and protective groups. In relative liver weight no changes in all groups except decease in R. chalepensis group. In serum ASAT levels, no changes in all groups except decrease in therapeutic group. Serum ALP levels increased in therapeutic group and highly significantly increased in KBrO3 group. There were increases in total protein levels in all groups. Albumin levels, increased in KBrO3 group and highly increased in protective and therapeutic groups. In conclusion, the administration of R. chalepensis oil extract against KBrO3 toxicity was not beneficial as protective and curative effects in adult male rats.
DOI: 10.54172/v2nwk236
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4403183256