Antioxidant activity and radioprotective effects of oral administration of vitis vinifera L. seed in wistar rats following fractionated whole-brain irradiation.
Year: 2024
Type: article
Abstract: Background: Chronic oxidative stress is hypothesized to precede radiation-induced brain injury in irradiated brains.This study investigated the antioxidant activity and radioprotective effects of Vitis vinifera L. seed in Wistar rats following fractionated whole-brain irradiation.Materials and Methods: Seventy-two young adult male Wistar rats were randomly selected and divided into three equal groups.Group A was the control group, while Groups B and C received a total dose of 40 Gy of 60 Co gamma radiation to the head.The radiation dose was fractionated at 5 Gy per exposure.In addition, group C rats were orally administered 100 mg/kg/day of Vitis vinifera L. seeds starting from one week before exposure and lasting until the time of sacrifice.At weeks 1, 2, 3, and 4 post-irradiations, the average brain weights, total brain protein concentration, and superoxide dismutase activity of the rat brains were determined. Results:The study recorded significant reductions in the average brain weights, total brain protein concentration, and brain superoxide dismutase activity in group B rats when compared to groups A and C (P < 0.05).However, the study found that group C rats had a higher total brain protein concentration (P > 0.05), correlative average brain weight (P > 0.05), and a significant increase in brain superoxide dismutase activity (P < 0.05) when compared with group A rats.Conclusions: Vitis vinifera L. seed has antioxidant and radioprotective effects on irradiated rat brains.
Authors: A.A Abe, O.A Ayannuga, F.A Balogun
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4403573705