Design, Synthesis and Anticancer Activity of Unsymmetrically Substituted Urea Based Small Molecules against Human Breast Cancer (MCF7) Cell Lines
Year: 2024
Type: article
Abstract: In the present investigation urea-based small molecules with unsymmetrical substitutions were synthesised and their in vitro cytocoxic activity was assessed against Human breast cancer (MCF7) cell lines.The title compounds (UDa -UDl) were synthesised in two steps and their in vitro cytotoxic activity was evaluated using MTT assay method.All the compounds showed effective cytotoxic activity against the tested cell line with the IC50 value ranges between 41.99 -156.52 ug/ml.Among the compounds tested, UDl exhibited potent cytotoxic activity with a IC50 value of 41.99 ug/ml.Compound UDf, UDi and UDk showed IC50 values of 48.64, 51.08 and 52.27 ug/ml, respectively.Compounds UDe and UDc exhibited moderate cytotoxic activity and the remaining compounds showed mild activity against the tested cell lines.Camptothecin was used as a standard drug which showed the IC50 value as 19.95 ug/ml.
Authors: Periyasamy Gomathi, Rajala Srikala, Satrasala Neelima, Cherukupally Rathnakar, Srikanth Kumar Karumanchi, Thakkalapally Shalini
Institutions: Guru Nanak Institutions, Chaitanya
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4403573809