Year: 2024
Type: book-chapter
Abstract: This chapter showcases the potential of cell-derived extracellular nanovesicles (EVs) as an alternative platform for the development of nanoparticle-based vaccines. Exosomes are one such tiny cell secretory vesicles, responsible for multiple biological functions including intercellular communication and host pathogen interactions. Their innate characteristics of excellent biocompatibility, low immunogenicity, targeted delivery, and high permeability offer them as a promising platform for an effective vaccine development. Here, we tried to discuss several aspects of exosome-based vaccines including their prospects and associated challenges for their successful clinical translation. Exosomes as a platform for the generation of nanoparticle-based vaccines may aid in the discovery of innovative and effective vaccine development strategies for a broad range of diseases.
Source: Pharmaceutical science.
Authors: Jaeyoung Kim, Nikita Thapa
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4403740800