Year: 2024
Type: book-chapter
Abstract: There has been a growing concern in recent years regarding the potential for reproductive and developmental toxicity resulting from the excessive use of drugs. There are several gaps in the present understanding of reproductive and developmental toxicity and few validated assays to assess the effects of drugs on various stages of the reproductive and developmental cycle because this area of toxicology had not received much attention before. This chapter provides a closer look at several types of drugs, with particular emphasis on the reproductive toxicity associated with the anticancer drug doxorubicin, the detrimental impacts of methotrexate on rapidly proliferating reproductive cells, and the growing apprehension regarding the possible damage of the reproductive systems by antidepressants. Furthermore, corticosteroids also have adverse effects on the reproductive and developmental cycles. To mitigate potential hazards, this thorough analysis highlights the need for a nuanced knowledge of drug-induced reproductive and developmental toxicity. It also emphasizes the need of more research and a holistic strategy for drug safety assessment.
Authors: RABIA AZMAT, MARYAM JAMEEL, AMARA TAHIR, MUHAMMAD MAKHDOOM JALAL, MUHAMMAD UMAR IJAZ, HAMMAD AHMAD KHAN, MUHAMMAD FAISAL HAYAT, ALI AKBAR
Institution: University of Agriculture Faisalabad
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4403787754