Work

Evaluating the effects of different doses of fimasartan on methotrexate-induced renal inflammation in rats

Year: 2024

Type: article

Abstract: The nephrotoxicity induced by methotrexate is a severe condition that greatly affects its therapeutic potential and has a significant inflammatory component. Fimasartan is an angiotensin receptor blocker that offers organ-protective effects and may be useful in mitigating renal injury. The present study explored the anti-inflammatory potential of two doses of fimasartan against methotrexate-mediated nephrotoxicity. Albino rats were intraperitoneally administered a single methotrexate (20 mg/kg).

Source: Journal Of Advanced Pharmacy Education And Research

DOI: 10.51847/sndwaqwohx

Authors: Ali Faris Hassan, Maryam Rasheed Abd, Shihab Hattab Mutlag, Sajida Hussein Ismael, Aisha Muthanna Shanshal, Ihsan Khudair Jasim

Institutions: University of Baghdad, Nahrain University, Al-Turath University

Language: English

Topic: Chemotherapy-induced organ toxicity mitigation

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: University of Baghdad