Association of the expression of Bcl-2 and Ki-67 prognostic markers and apoptotic index with biological behaviour in aggressive and non-aggressive non-melanoma eyelid skin cancer
Year: 2024
Type: article
Study design: Observational Study
Abstract: Introduction: Prognostic biomarkers facilitate the identification of high-risk tumours.Aim: To evaluate the association of Bcl-2 protein and Ki-67 antigen expression and the apoptotic index with biological behaviour of non-melanoma eyelid tumours.Material and methods: Combined analysis of retrospective and prospective study of data from two centres over a period from 2008 to 2023 on histologically confirmed malignant non-melanoma eyelid tumours without any age limitation.Selected prognostic markers related to the aggressive or non-aggressive tumour types were evaluated.Results: The study cohort included 68 patients with 70 non-melanoma eyelid tumours (n = 70).The basal cell carcinoma was the most frequently present type (97.1%).The median age was 68 years.A tumour size > 5 mm correlates to the aggressive type (p = 0.047).Resection margins < 2 mm were in 33.9%, without any connection to the recurrence rate (p = 0.076).The average value of Bcl-2 expression in non-aggressive types was 82.65% (p < 0.001).The value of Ki-67 expression in patients with non-aggressive tumours was 35.49% (p = 0.068).Non-aggressive tumours most frequently exhibited the apoptotic index of Grade I (p = 0.535).No Grade III case was observed in the aggressive types.In 2 cases, the orbital exenteration was carried out (0.03%).In 1 case biological therapy was administered.HDR brachytherapy was applied in 6 cases.A recurrence of the disease was observed in 4 (0.06%) cases.Conclusions: New information on cancer biomarkers in non-melanoma eyelid skin carcinoma contributes to choosing a correct therapy with achieving good aesthetic results and a good survival rate.
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $472
OpenAlex ID: W4404489874