Neuroinflammation in Age-Related Neurodegenerative Diseases: Role of Mitochondrial Oxidative Stress
Year: 2024
Type: article
Abstract: A shared hallmark of age-related neurodegenerative diseases is the chronic activation of innate immune cells, which actively contributes to the neurodegenerative process. In Alzheimer's disease, this inflammatory milieu exacerbates both amyloid and tau pathology. A similar abnormal inflammatory response has been reported in Parkinson's disease, with elevated levels of cytokines and other inflammatory intermediates derived from activated glial cells, which promote the progressive loss of nigral dopaminergic neurons. Understanding the causes that support this aberrant inflammatory response has become a topic of growing interest and research in neurodegeneration, with high translational potential. It has been postulated that the phenotypic shift of immune cells towards a proinflammatory state combined with the presence of immunogenic cell death fuels a vicious cycle in which mitochondrial dysfunction plays a central role. Mitochondria and mitochondria-generated reactive oxygen species are downstream effectors of different inflammatory signaling pathways, including inflammasomes. Dysfunctional mitochondria are also recognized as important producers of damage-associated molecular patterns, which can amplify the immune response. Here, we review the major findings highlighting the role of mitochondria as a checkpoint of neuroinflammation and immunogenic cell deaths in neurodegenerative diseases. The knowledge of these processes may help to find new druggable targets to modulate the inflammatory response.
Source: Antioxidants
Institutions: Consejo Superior de Investigaciones Científicas, Instituto de Salud Carlos III, Biomedical Research Networking Center on Neurodegenerative Diseases, Centro de Investigación Biomédica en Red, Institut d'Investigacions Biomèdiques de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Vall d'Hebron Institut de Recerca, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,296
Awards: G1005157577, G1175115578, G1341303, G1622782223, G210041235, G2262748287, G2355262757, G2601397997, G2672435700, G288263039, G300979063, G34346518, G3480869486, G3681454997, G4042783231, G410571670, G425668148, G451917667, Participación de las trampas extracelulares de neutrófilos (NETs) en la esteatohepatitis no alcohólica (EHNA): contribución a la sepsis y enfoque de género., G5080475149, G5195188938, Validación de biomarcadores líquidos y de imagen para el diagnóstico de la demencia con cuerpos de Lewy prodrómica, G5539308778, G5852091828, G5856237390, G5967599077, G7084143925, G8696694383, G929308097
OpenAlex ID: W4404635651