Epidermal Growth Factor Receptor: Prognostic Marker For Undifferentiated Nasopharynx Carcinomas North-African Patients
Year: 2024
Type: article
Study design: Observational Study
Abstract: Epidermal growth factor receptor (EGFR) is overexpressed in many different cancers and is involved in the regulation of cellular metabolism, growth, migration and differentiation.EGFR expression in UNCT (undifferentiated carcinoma of nasopharyngeal type) has been previously reported for Asian patients, and, as for other head and neck locations, is overexpressed in 80% of cases and is associated with poor prognosis.The nasopharyngeal cancers have an endemic apportionment affecting overwhelmingly East Asia and North Africa, however, at this time, no studies have been conducted in this latter population.The objective of the present study is to evaluate for the first time at first on a North African population, the correlation between the expression of EGFR and prognosis in UCNT.The medical records of 70 Algerian UCNT patients who had undergone biopsy prior to chemotherapy and radical radiotherapy between 2003 and 2007 were retrospectively reviewed.Patients were followed-up until death.Immunohistochemistry was used to evaluate the expression of EGFR in UNCT biopsy specimens, and the association between their expression and clinical parameters and survival was analyzed.In 56 out of 70 (80%) UNTC patients EGFR was overexpressed.EGFR overexpression is significantly correlated to disease-free (p= 0.0008) and overall survival (p= 0.0001).As in Asian countries and other head and neck cancers, EGFR is a powerful prognostic marker in UCNT Maghreb population.Its therapeutic targeting in UCNT deserves to be assessed in a clinical phase III trial.
Source: HAL
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4404836244