Work

Author response: Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus

Year: 2024

Type: peer-review

Abstract: This important manuscript provides an extensive and convincing analysis of the foetal and adult TCR repertoire in the mouse thymus.A potential implication of the work is that the earliest appearing T cells during ontogeny may have properties that are fundamentally distinct from those appearing later in life.The study will be of interest to immunologists concerned with T cell development and TCR repertoires.

Source: eLife

DOI: 10.7554/elife.93493.3.sa3

Authors: Jasmine Rowell, Ching-In Lau, Susan Ross, Diana Yanez, Oscar A Peña, Benny Chain, Tessa Crompton

Institutions: University College London, University of Bristol

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: National Institute for Health and Care Research, Directorate for Biological Sciences, Medical Research Council, Biotechnology and Biological Sciences Research Council, Great Ormond Street Institute of Child Health

Awards: Impact of Hedgehog signalling on the T cell receptor (TCR) repertoire, Hedgehog signalling in gamma delta T-cell differentiation, Foxa1/A2, Shh and Gli3 in T lymphocyte development, Hedgehog signalling in peripheral T cell differentiation and function

OpenAlex ID: W4405073718

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