Geographical variation in lung function: Results from the multicentric cross-sectional BOLD study
Year: 2024
Type: article
Abstract: Spirometry is used to determine what is “unusual” lung function compared with what is “usual” for healthy non-smokers. This study aimed to investigate regional variation in the forced vital capacity (FVC) and in the forced expiratory volume in one second to FVC ratio (FEV1/FVC) using cross-sectional data from all 41 sites of the multinational Burden of Obstructive Lung Disease study. Participants (5,368 men; 9,649 women), aged ≥40 years, had performed spirometry, had never smoked and reported no respiratory symptoms or diagnoses. To identify regions with similar FVC, we conducted a principal component analysis (PCA) on FVC with age, age2 and height2, separately for men and women. We regressed FVC against age, age2 and height2, and FEV1/FVC against age and height2, for each sex and site, stratified by region. Mean age was 54 years (both sexes), and mean height was 1.69 m (men) and 1.61 m (women). The PCA suggested four regions: 1) Europe and richer countries; 2) the Near East; 3) Africa; and 4) the Far East. For the FVC, there was little variation in the coefficients for age, or age2, but considerable variation in the constant (men: 2.97 L in the Far East to 4.08 L in Europe; women: 2.44 L in the Far East to 3.24 L in Europe) and the coefficient for height2. Regional differences in the constant and coefficients for FEV1/FVC were minimal (<1%). The relation of FVC with age, sex and height varies across and within regions. The same is not true for the FEV1/FVC ratio.
Source: Pulmonology
Authors: Peter G.J. Burney, James Potts, Ben Knox-Brown, Gregory Erhabor, Hamid Hacene Cherkaski, Kevin Mortimer, Mahesh Padukudru Anand, David M Mannino, Joao Cardoso, Rana Ahmed, Asma Elsony, Cristina Barbara, Rune Nielsen, Eric Bateman, Stefanni Nonna M Paraguas, Li Cher Loh, Abdul Rashid, Emiel FM Wouters, Frits ME Franssen, Hermínia Brites Dias, Thorarinn Gislason, Mohammed Al Ghobain, Mohammed El Biaze, Dhiraj Agarwal, Sanjay Juvekar, Fatima Rodrigues, Daniel O Obaseki, Parvaiz A. Koul, Imed Harrabi, Asaad A Nafees, Terence Seemungal, Christer Janson, William M Vollmer, Andre FS Amaral, A Sonia Buist
Institutions: Imperial College London, Ekiti State University, Adekunle Ajasin University, Obafemi Awolowo University Teaching Hospitals Complex, Obafemi Awolowo University, Badji Mokhtar-Annaba University, University of Cambridge, Liverpool University Hospitals NHS Foundation Trust, JSS Academy of Higher Education and Research, JSS Medical College and Hospital, University of Kentucky, COPD Foundation, Unidade Local de Saúde de São José, Universidade Nova de Lisboa, University of Lisbon, Centro Hospitalar Lisboa Norte, Haukeland University Hospital, University of Bergen, University of Cape Town, Philippine Heart Center, RCSI & UCD Malaysia Campus, Sigmund Freud Privatuniversität Wien, Maastricht University Medical Centre, Universidade Politécnica de Lisboa, University of Iceland, National University Hospital of Iceland, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Sidi Mohamed Ben Abdellah University, Laboratório Associado TERRA, University of British Columbia, Sher-i-Kashmir Institute of Medical Sciences, University of Sousse, Aga Khan University, Aga Khan University, University of the West Indies, University of the West Indies, Uppsala University, Kaiser Permanente Center for Health Research, NIHR Imperial Biomedical Research Centre, Oregon Health & Science University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funders: Pfizer, AstraZeneca, GlaxoSmithKline, Air Liquide, Guangzhou Medical University, Wellcome Trust, Chest Research Foundation, International Development Research Centre, Pfizer Australia, GlaxoSmithKline Australia, South African Medical Research Council, South African Thoracic Society, Landspítali Háskólasjúkrahús, Medizinischen Hochschule Hannover, Paracelsus Medizinische Privatuniversität, AstraZeneca Pharma Poland, Medical Research Council, Policy Research
OpenAlex ID: W4405114885