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Synthesis of 3-Alkyl-5-(diethylaminomethyl)-1-(1,3-thiazole)pyrazoles

Year: 2024
Type: article
Abstract: By the reaction of 3-alkyl-5-(diethylaminomethyl) pyrazoles with chloroanhydride of monochloroacetic acid, the pyrazoles with chloromethyl carbonyl substituent have been synthesized. Due to presence of reactive COCH2Cl groups in a molecule, the pyrazoles have been subjected to heterocyclization with thicarbamides (thiobenzamide, thicarbamide and phenylthiocarbamide) in the presence of triethyleamine in a medium of ethanol, as a result of which the previously unknown 3-alkyl-5-diethylaminomethyl-1-(1,3-thiazol)substituted pyrazole derivatives have been obtained.
Language: English
Field: Chemistry
Open Access status: bronze
OpenAlex ID: W4405133751
FWCI:
Cites: 19
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Related to: 10