Impaired maternal central hemodynamics precede the onset of vascular disorders of pregnancy at high altitude
Year: 2024
Type: article
Study design: Observational Study
Abstract: In this prospective study of maternal central hemodynamics at high altitude, pregnancies later affected by preeclampsia (PE) and/or fetal growth restriction (FGR) show elevated systemic and uterine vascular resistance and reduced stroke volume as early as 10-16 wk gestation. Maternal hemodynamic assessments could facilitate early detection of high-risk pregnancies, improving resource allocation and reducing adverse outcomes. We propose an integrated model linking maternal cardiovascular performance to placental insufficiency, enhancing the understanding of PE-FGR in high-altitude settings.
Authors: Rosalieke E. Wiegel, Kori Baker, Carla Calderon-Toledo, Richard Gomez, Sergio Gutiérrez-Cortez, Julie A. Houck, Alison Larrea, Litzi Lazo-Vega, Lorna G. Moore, Julia Pisc, Lilian Toledo-Jaldin, Colleen G. Julian
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: Epigenetic and Fetal Origins of Hypoxia-Induced Pulmonary Hypertension, Antenatal Exposures and Non-Communicable Disease(ANDES): Building research capacity to identify and treat causes of NCD in Bolivia, G7239360530, Effects of chronic hypoxia and AMPK activation on uteroplacental perfusion, placental metabolism and the regulation of fetal growth, Novel roles of purinergic signaling for altitude-associated fetal growth restriction, Novel NF-kB variant in preeclampsia
OpenAlex ID: W4405220146