Quantitative Assessment of Peritumorous Cd8+ T - Lymphocytes as a Prognostic Factor in Renal Cell Carcinoma: Clinical and Pathological Comparisons
Year: 2024
Type: conference-paper
Abstract: The aim of the study was to evaluate the prognostic value of quantitative CD8+ T-lymphocyte counts in the peritumoral zone of renal cell carcinoma. Materials and methods. The material of 74 patients after surgical treatment for renal cell carcinoma with a complete 5-year follow-up was retrospectively analyzed. Of the 74 patients, 56 were alive at 5-year follow-up, and 18 died of cancer. After immunohistochemical staining, the distribution density of CD8+ T-lymphocytes in the peritumorous zone of carcinomas was determined in 3 representative fields of view at a magnification of x 400 and comparisons were made with the clinicopathological characteristics of tumors and the overall 5-year survival of patients. Results. A high level of infiltration of the peritumorous zone of carcinomas with CD8+ T-lymphocytes was observed in stages III-IV of the disease (p = 0.0000001), in tumors >7 cm (p = 0.0000001), in grades III-IV anaplasia according to Fuhrman (p = 0.001 ), in the presence of metastases (p = 0.0000001) and with shorter overall patient survival (p = 0.0003). A high content of CD8+ T-lymphocytes was also noted in men (p = 0.001) and in cases of unclassified cancer. Conclusion. In light of the need to search for new prognostic criteria for kidney cancer, we conclude that a high level of infiltration of the peritumoral zone with CD8+ T lymphocytes is an unfavorable prognostic factor. Assessment of infiltration of the peritumoral zone of kidney cancer with CD8+ T lymphocytes can serve as an additional prognostic factor that can predict the course of the disease at the preoperative level.
Authors: I.P. Bobrov, E.S. Dolgatova, A.Y. Dolgatov
Institution: Altai State Medical University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4405259297