High Expression of Cd3+ T Lymphocytes in the Peritumorous Zone as an Unfavorable Prognostic Factor in Renal Cell Carcinoma
Year: 2024
Type: conference-paper
Abstract: The work carried out a quantitative analysis of CD3 + T-lymphocytes in the peritumorous zone (PZ) of renal cell carcinoma. Paraffin blocks of postoperative material from 74 patients with kidney cancer were studied. The study included 36 (50%) men and 37 (50%) women. The average age of the patients was 56.7±1.1 years. The number of CD3 + T-lymphocytes in the tumor PZ increased by 4.5 times (p = 0.0000001) at stages III-IV of the disease, by 6.7 times (p = 0.001) at stages III-IV atypia, by 2 .3 times (p = 0.0000001) when the size of the tumor node is more than 7 centimeters and 2.7 times (p = 0.0000001) in the presence of metastases. In non-crusifying cancer, the number of CD3+ T-lymphocytes in the prostate was the highest (161.3±26.7), and the lowest value was in papillary carcinoma (85.9±31.0) (p = 0.05). A high content of CD3+ T-lymphocytes in PZ carcinomas is associated with an unfavorable course of the disease, and this parameter can be used as an additional prognostic factor in renal cell carcinoma.
Authors: I.P. Bobrov, E.S. Dolgatova, A.Y. Dolgatov
Institution: Altai State Medical University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4405259592