Year: 2024
Type: article
Abstract: Herein, we disclose a new photochemical process to prepare γ‐amino acids from allylamines and formic acid salts. The investigated redox‐neutral hydrocarboxylation process produces high yields across a wide range of functionalized allylamine substrates with excellent regioselectivity. The developed operationally simple protocol can be readily scaled with low photocatalyst loading (from 1% up to 0.02 mol%) without the need for any precautions to exclude air or moisture. The mechanistic working model utilizes a thiol‐catalyzed radical chain process, delivering the hydrogen atom and CO 2 from formic acid salt across the alkene substrate through the carboxylate radical (CO 2 ⋅ − ), a crucial reactive intermediate.
Source: Advanced Synthesis & Catalysis
Institutions: Institute of Organic Chemistry, Polish Academy of Sciences
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4405308317