Work

DNA double-strand break repair capacity and normal tissue toxicity induced by radiotherapy

Year: 2024

Type: review

Abstract: Radiation therapy is used in the treatment of various cancers, and advancements in irradiation techniques have further expanded its applicability. For radiation oncologists, predicting adverse events remains a critical challenge, even with these technological advancements. Although numerous studies have been conducted to predict individual radiosensitivity, no biomarkers have been clinically applied thus far. This review focuses on γ-H2AX foci and chromosomal aberrations, providing an overview of their association with normal tissue toxicities.

Source: Journal of Radiation Research

DOI: 10.1093/jrr/rrae081

Authors: Ikuno Nishibuchi, Satoshi Tashiro

Institutions: Hiroshima University, Research Institute for Radiation Biology and Medicine, Hiroshima University

Language: English

Topic: Effects of Radiation Exposure

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,503