Endometrial hyperplasia, benign endometrial tumors and endometrial carcinoma: A review study
Year: 2024
Type: article
Abstract: Background. During the reproductive phase, the endometrium undergoes cyclical structural changes. Endometrial hyperplasia (EH) is a prevalent condition that arises from a combination of estrogen exposure and insufficient progesterone levels. Endometrial cancer (EC) is the second most common gynecologic malignancy, with the likelihood of EH progressing to EC ranging from 1% to 29%. The objective of this study is to conduct a comprehensive assessment of various forms of endometrial hyperplasia, benign endometrial tumors, and endometrial cancer (EC). Methods. A review of published papers from major databases, including PubMed, Scopus, and Google Scholar, was conducted. The search included original research articles and reviews on EH, benign endometrial tumors, and EC. Case reports, series, and clinical images were excluded. Results. Information on the selected topics was summarized, including epidemiology, etiology, histopathological classification, anatomy, biological and molecular characteristics, detection and prevention, clinical manifestations, staging, diagnostic workup, prognostic factors, and management. Conclusion. Endometrial hyperplasia and endometrial cancer are two of the most common problems in women. EH is a major precancerous condition for EC, and EC is associated with a poor prognosis if diagnosed late. The epidemiology and outcomes of both conditions vary according to several factors, including ethnicity, environment, socioeconomic status, heredity, drugs, hormones, and the aging process.
Source: Romanian Medical Journal
Author: Ahmed Salih Alshewered
Institution: Ministry of Health
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $192
OpenAlex ID: W4405536086