Exploring the antimicrobial and anti-HIV-1 properties of Anthocleista djalonensis, Vernonia cinerea, and Pycnanthus angolensis extracts
Year: 2024
Type: article
Abstract: This study examined the anti-HIV-1 integrase, protease, and antimicrobial properties of crude extracts from three traditional Nigerian medicinal plants: Anthocleista djalonensis , Vernonia cinerea , and Pycnanthus angolensis . Fluorometric assays were utilized to assess the inhibitory effects of crude extracts produced through maceration on HIV-1 integrase and HIV-1 protease. The samples' antimicrobial activity was measured using microdilution methods. The results showed that all three crude plant extracts significantly inhibited HIV-1 integrase activity with IC 50 values of 0.01891, 0.709, and 5.21 μg/mL for A. djalonensis, V. cinerea , and P. angolensis respectively. IC 50 value of 0.006992 μM was recorded for chicoric acid used as the reference medication for anti-HIV-1 integrase activity. This allowed for comparison with the crude extracts from V. cinerea, P. angolensis, and A. djalonensis. Conversely, the methanol crude extract from A. djalonensis , V. cinerea , and P. angolensis did not show a dose response since none of the extracts could reduce a specific percentage of viable cells in the HIV-1 protease assay. This data provides vital information on the preference for A. djalonensis , V. cinerea , and P. angolensis extracts towards HIV-1 integrase rather than protease even though it may initially seem unexpected. A. djalonensis, V. cinerea , and P. angolensis extracts exhibited antibacterial activities against all pathogens with the minimum inhibitory concentrations (MIC) ranging between 8 and 67 μg/mL. The study underscores the potential of plant extracts as innovative treatments for HIV-1 infection, as they can provide anti-HIV-1 integrase inhibitors. The ethnopharmacological perspective thus confirms the significance of African traditional medicines.
Source: Discover Chemistry.
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4405825035