Work

Regenerative potential of Concentrated Growth Factor (CGF) Membrane in an Induced Bone Defect Model in Rabbits: A Light Microscopic and Histomorphometric Study

Year: 2025

Type: article

Abstract: Background:There is an increasing demand for innovative biomaterials and techniques in dental practices to improve regenerative therapies. Researchers have employed guided bone regeneration (GBR) using biologically compatible membranes to repair bone defects. These membranes promote bone healing by ensuring biocompatibility and mechanical stability, and they address issues like edentulous ridges and extraction sockets. This study evaluates the effectiveness of concentrated growth factor membrane (CGF) as a regenerative material for bone defects in rabbits, using histochemical and histomorphometric analysis to assess bone matrix maturation.Materials and methods: The study included 36 male New Zealand rabbits, each with a one-wall bone defect created near the lower left first molar. The rabbits were divided into two groups: Group I (defects without CGF treatment) and Group II (defects treated with a CGF membrane). Each group was further divided into three subgroups (a, b, and c) based on time intervals of 7, 30, and 45 days. One-way ANOVA was used to analyze and compare the data. Results: The highest statistically significant mean value was observed in Group II, Subgroup C (48.31 ± 10.36), while the lowest values were seen in both Group I and Group II, Subgroup A, with mean values of 0.00 ± 0.00, indicating no significant difference between these subgroups.Conclusions: CGF membrane demonstrated great potential for GBR, significantly accelerating bone formation in one-wall defect compared to controls, particularly at 45-days interval. It shows potential for clinical applications improving outcomes for patients undergoing GBR therapies.

Source: Egyptian Dental Journal /Egyptian Dental Journal

DOI: 10.21608/edj.2024.328049.3234