Efficacy and Safety of Mycophenolate Mofetil (MMF) vs Azathioprine (AZA) for Treatment Naive Autoimmune Hepatitis: A Systematic Review and Meta-analysis
Year: 2025
Type: study-registration
Abstract: eview question / Objective Evaluation of Efficacy and Safety of Mycophenolate Mofetil versus Azathioprine in Treatment-Naïve Autoimmune Hepatitis Patients age > 18 years of age.Condition being studied Autoimmune Hepatitis, which is characterized by autoimmune attack on liver cells. METHODS Participant or population Treatment-Naïve Autoimmune Hepatitis Patients age > 18 years of age.Intervention Mycophenolate Mofetil. Comparator Azathioprine. Study designs to be included RCT, Case Cohort studies.Eligibility criteria Inclusion criteria were meticulously defined to include all comparative studies, including Randomized Controlled Trials (RCTs) and observational studies, which compared MMF vs AZA for AIH in treatment-naïve patients.Eligible studies had to meet the following criteria: (1) Adult participants (≥18 years); (2) Intervention: Mycophenolate Mofetil regimen for AIH patients;(3) Control: Azathioprine regimen for AIH patients; (4) Outcomes: Complete Biochemical Response (CBR), corticosteroid withdrawal rates, relapse rates, treatment response, and safety outcomes.Excluded were case reports, case series with fewer than ten patients, single-arm studies, guidelines, and non-comparative studies.Priority was given to the most comprehensive and recent publications in cases of overlapping data.Additionally, literature reviews, duplicates, conference proceedings, animal studies, and unpublished articles were excluded.
Language: English
Topic: Liver Diseases and Immunity
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4406089448