Case report: Kinetics of viral load, immunoglobulins, and cytokines in a fatal case of Crimean-Congo hemorrhagic fever virus
Year: 2025
Type: article
Study design: Case Report
Abstract: A fatal case of Crimean-Congo hemorrhagic fever virus (CCHFV) was detected in Dakar, Senegal, West Africa, in April 2023. To elucidate the mechanisms involved in this outcome, the kinetics of viral load, immunoglobulins, and cytokines were assessed using RT-qPCR and ELISA. A high IL-6 titer, low IL-10 titer, and delayed IgG response were associated with disease severity. These biomarkers may serve as predictors of disease severity, potentially aiding in early intervention and treatment strategies.
Source: Frontiers in Virology
Institutions: Institut Pasteur de Dakar, Cheikh Anta Diop University
Language: English
Topic: Viral Infections and Vectors
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,353
OpenAlex ID: W4406132338