Exploring the Versatility of Azine Derivatives: A Comprehensive Review on Synthesis and Biological Applications
Year: 2025
Type: article
Study design: Systematic Review
Abstract: Organic compounds containing azines, di-imines, or bis-Schiff-bases have two azomethine (-CH=N-) functional groups associated with a bridging component. These constituents have attracted attention from a diversity of disciplines, comprising coordination, medicinal, agriculture chemistry, and organic synthesis, because of their comprehensive chemical reactivity and nature. This study determines common synthetic approaches and various biological and pharmacological activities of several substituted bis-Schiff byproducts. The usefulness of bis-Schiff bases in synthetic chemistry and their potential as inhibitors of a number of enzymes have attracted research attention. We have examined different biological activities and common synthetic methods used to make bis- Schiff bases that have been published in the literature. A systematic search of the literature has been performed, and studies fitting the prearranged inclusion standards have been inspected. This review can open up new potentials for upcoming research in this area and advance our information on bis- Schiff bases.
Authors: Saeed M.N. Alasmari, Aftab Alam, Aftab Alam, Fayaz Ur Rahman, Ahmed A. Elhenawy, Abid Ali, Manzoor Ahmad, Manzoor Ahmad, Momin Khan
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4406404792