Basement Membrane Alterations in Oral Lichen Planus and Oral Squamous Cell Carcinoma: Correlation with Laminin 5 Gamma 2 Expression
Year: 2025
Type: article
Abstract: Oral lichen planus (OLP) is a prevalent chronic inflammatory disease that primarily affects middle-aged women. There is a substantial chance that OLP lesions will acquire a cancerization field and undergo malignant transformation. Laminin 5 gamma 2, a key component of the epithelial basement membrane, was studied in oral lichen planus and oral squamous cell carcinomas using immunohistochemical methods in this study to understand its function. Ten cases each of clinically and histopathologically confirmed oral lichen planus and oral squamous cell carcinoma were included in this study. The stain distribution in each OLP and OSCC cases were observed in the basement membrane. Immunohistochemical expression of laminin 5 gamma 2 shows a continuous line of staining in the basement membrane in 8 cases of OLP. In oral squamous cell carcinoma most cases (5/10) showed a discontinuous basement membrane immunohistochemical staining pattern. In accordance to this study, laminin expression is more strongly associated with the malignant potential of premalignant lesions such as OLP, and its total absence indicates a poorly differentiated carcinoma.
Authors: Sabu Paul -, Manjusha Mohanan -, Latha Mary Cherian -, Kristina Sabu -
Institution: Government Medical College
Language: English
Subfield: General Dentistry
Field: Dentistry
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4406622017