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Ocular pseudopemphigoid associated with pembrolizumab immunotherapy

Year: 2025

Type: article

Abstract: We describe an unusual case of bilateral ocular pseudopemphigoid associated with pembrolizumab therapy for stage IV lung adenocarcinoma. A 66-year-old man presented with bilateral scarring conjunctivitis, symblepharon formation, forniceal foreshortening, epithelial defects, and mild corneal edema, simulating ocular mucus membrane pemphigoid. No blisters or ulcers were found elsewhere. Diagnosis revealed an immune-related adverse event secondary to immune checkpoint inhibitors. Treatment involved pembrolizumab discontinuation and high-dose oral corticosteroids in addition to adjunctive topical therapies, which led to gradual but complete visual recovery over 4 months. This case highlights the importance of recognizing and managing rare ocular manifestations of immune checkpoint inhibitors quickly.

Source: Indian Journal of Ophthalmology - Case Reports

DOI: 10.4103/ijo.ijo_732_24

Authors: Andrea Martín-Herrero, Maria del Mar Prieto-del-Cura, Vyara Hristova-Yadkova, María José Crespo Carballés

Institution: Hospital Universitario Infanta Leonor

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4406950883

FWCI:

Cites: 11

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Related to: 10