Work

Efficiency comparison between new single‐needle dialysis and conventional double‐needle dialysis and exploration of the optimal prescription parameters for single‐needle hemodialysis

Year: 2025

Type: article

Abstract: OBJECTIVE: To compare the dialysis efficiency parameters between new single-needle dialysis and conventional double-needle dialysis and to explore the optimal prescription parameters for single-needle hemodialysis. METHODS: This study involved a prospective, cross-over design. Eight patients were randomly divided into two cohorts, which received the appropriate treatment. Relevant clinical data and dialysis-related parameters were collected for further analysis. RESULTS: Each of the patients enrolled in this study underwent nine sessions of single-needle dialysis and three sessions of double-needle dialysis. The average blood flow after 4, 4.5, and 5 h of single-needle dialysis was significantly lower (p < 0.001) than that with double-needle dialysis for the equivalent times. The online Kt/V value measured after 4 h of single-needle dialysis was significantly lower than that with 4 h of double-needle dialysis (p < 0.001). When replacing the dialyzer with a high-flux dialyzer (FX800) and extending the dialysis time to 5 h, there was no difference in the online Kt/V values (p = 0.341). There was also no difference in the ultrafiltration volume between single-needle and double-needle dialysis for the equivalent times. The calculation of the Kt/V and urea reduction rate (URR) showed that there was no difference between 5 h of single-needle dialysis and conventional double-needle dialysis (p > 0.05). CONCLUSIONS: The new modified single-needle system is safe and effective to support the dialysis treatment of maintenance hemodialysis patients. When adjusting the dialysis prescription to a high-flux dialyzer and extending the dialysis time to 5 h, it can achieve dialysis efficiency equivalent to that of conventional 4 h double-needle dialysis.

Source: Therapeutic Apheresis and Dialysis

DOI: 10.1111/1744-9987.70006