Work

106P Screening of TROP2 and Nectin-4 in osteosarcomas: In pursuit of a target

Year: 2025

Type: article

Abstract: Osteosarcoma (OS), the most common malignant bone tumor, primarily affects adolescents and young adults and is associated with poor outcomes, particularly for recurrent or metastatic cases. This highlights the need for prognostic and predictive biomarkers and novel therapeutic targets. Trophoblast cell surface antigen 2 (TROP2) is a transmembrane glycoprotein that facilitates the transmission of intracellular calcium signals, while Nectin-4 is a transmembrane protein that plays a vital role in cell-to-cell adhesion.

Source: ESMO Open

DOI: 10.1016/j.esmoop.2025.104419