Exploratory Study to Evaluate the Impact of Interim PET/CT Assessment in First-Line Follicular Lymphoma
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background/Objectives: This study aimed to determine whether interim PET/CT (iPET) scans could identify follicular lymphoma (FL) patients at high risk of relapse following first-line therapy. Methods: A total of 117 FL patients who underwent iPET scans were included, with responses interpreted using the Deauville score (DS). Progression-free survival (PFS) was evaluated over a median follow-up of 34 months. Results: Overall, 34% of patients were classified as iPET (+), with significantly worse estimated 5-year PFS compared to iPET (−) patients (34% vs. 76%, hazard ratio 4.3, p < 0.001). Multivariate analysis confirmed iPET (+) as an independent predictor of PFS. Conclusions: Interim PET results are significant predictors of PFS in FL first-line therapy and could inform response-adapted treatment strategies.
Source: Cancers
Authors: Maria Poza, Alejandro Martin-Muñoz, Patricia López-Pereira, Gloria Figaredo, Irene Zamanillo, Rodrigo Iñiguez, Ana Carla Oliveira, Tycho Baumann, Antonia Rodriguez-Izquierdo, Carlos Grande, Pilar Sarandeses, Enrique Revilla, Montserrat Cortes, Rosa Ayala, Maria Calbacho, Joaquin Martinez-Lopez, Santiago Barrio, Ana Jimenez-Ubieto
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Awards: G3325265670, G3422751472, G3624774042, Identificación temprana de pacientes con linfoma folicular con mal pronóstico combinando técnicas de EMR en biopsia líquida y PET/TC, G4755029145, COMBINACINACIÓN DE TÉCNICAS PERSONALIZADAS DE CtDNA y PET/TC PARA PRECERI EL FRACASO DEL TRATAMIETNO CON CÉLULAS CAR-T EN PACIENTES CON LINFOMA B DIFUSO DE CÉLULAS GRANDES REFRACTARIO O EN RECAÍDA., G6949338626, G7956387146, G8332879243
OpenAlex ID: W4408799641