Wolbachia: From Natural Variation to Genetic Engineering – Exploring Gene-Level Approaches for Next-Generation Dengue Control
Year: 2025
Type: book-chapter
Abstract: Dengue fever poses a significant global health challenge, particularly in tropical and subtropical regions. Current control strategies, heavily reliant on vector control, face limitations due to insecticide resistance and logistical challenges in large urban areas. This book chapter explores the innovative potential of Wolbachia bacteria as a biocontrol agent against dengue. Wolbachia infection in Aedes aegypti mosquitoes, the primary dengue vector, has demonstrated promising results in reducing both viral replication within the mosquito and onward transmission to humans. This chapter examines the complex mechanisms underlying Wolbachia’s antiviral effects, including both immune system modulation and competition for host cell resources. Furthermore, the role of gene expression changes in mediating these effects, highlighting the potential for long-term, sustainable dengue suppression, is discussed. While challenges remain in large-scale implementation and the potential for viral evolution, Wolbachia-based interventions offer a new avenue for integrated vector management and hold considerable promise for reducing the global burden of dengue fever. Gene drive technology and thorough testing, such as analyzing virus sequences, are also discussed to evaluate how well Wolbachia works.
Source: IntechOpen eBooks
Authors: Iqra Mushtaq, Ammara Chaudhry, Muhammad Sajjad Sarwar
Language: English
Subfield: Insect Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4408851156