Dental Pulp Stem Cell-Based Therapy for Human Diseases
Year: 2025
Type: article
Abstract: Stem cells, which can self-renew and develop into specialized cell types, are used in stem cell therapy, an emerging multidisciplinary approach, to repair and regenerate tissue. This medication may be beneficial for a variety of conditions, such as cardiovascular disease, neurological disorders, autoimmune diseases, and certain types of cancer. However, problems like safety, scalability, and ethical quandaries persist. Dental pulp stem cells (DPSCs), derived from the soft tissue of teeth, offer a clear advantage over other stem cell sources due to their accessibility and regeneration potential. DPSCs are valuable for immunological regulation, neurological therapy, and bone regeneration since they may be obtained non-invasively from extracted teeth and differentiate into a variety of cell types, including osteoblasts, adipocytes, and neurons. DPSCs can promote tissue healing and reduce inflammation due to their immunomodulatory qualities. They also release growth factors and cytokines, which help heal damaged tissues. In clinical settings, DPSCs still have limitations despite their potential, such as the need for homogeneity and scalability. However, because of their broad differentiation potential, ease of procurement, and immune-regulatory qualities, they are positioned as a promising resource in regenerative medicine. This review highlights the characteristics, mechanisms of action, and therapeutic potential of DPSCs in the treatment of diseases, with a special focus on their role in bone regeneration, tissue repair, and neuroprotection. Further research and clinical testing are needed to get past barriers and optimize the use of DPSCs in regenerative therapies.
Authors: Abirami Devendran, Yamini Anandan, Sankarganesh Palaniyandi, Ganesh Kumar Anbazhagan
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4408918679