The role of metal ion metabolism in the pathogenesis of diabetes and associated complications
Year: 2025
Type: review
Abstract: Diabetes is a growing health concern, accompanied by significant complications like cardiovascular disease, kidney disease, and retinopathy. Metal ions, including iron, zinc, and copper, play a crucial role in maintaining human health through their balance within the body. Disruptions in metal ion balance can intensify diabetic conditions. For instance, iron overload induces oxidative stress, which harms islet β cells and impacts vascular complications of diabetes. Abnormal copper levels heighten insulin resistance, and zinc deficiency has a strong connection with type 1 diabetes. Future in - depth exploration of the association between metal metabolism and diabetes holds the potential to uncover novel treatment avenues, enhancing both the quality of life and health prognosis for patients.
Source: Frontiers in Endocrinology
Authors: Siyuan Liu, Xuzhuo Chen, Xinrui Qi, Jiahao Bai, Bin Tong, Deju Zhang, Xiaoping Yin, Peng Yu
Language: English
Topic: Trace Elements in Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Award: G8433447111
OpenAlex ID: W4409105993