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Integrin α1 (ITGA1) is a novel biomarker of melanoma cells subjected to chemotherapy-induced senescence

Year: 2025
Type: article
Abstract: Background: Despite increasing knowledge of molecular biology of melanoma, the most aggressive type of skin malignancies, there is a need to screen specific markers of melanoma, especially drug-induced senescent melanoma. Chemotherapy-induced senescence may limit therapeutic outcome due to the accumulation of drug-resistant skin cancer cells and their removal based on specific targeting may represent a new promising strategy for preventing cancer recurrence.
DOI: 10.1016/j.ejcskn.2025.100478
Authors: J. Słaby, M. Wnuk, D. Błoniarz, P. Stec, T. Szmatoła, E. Kaznowska, A. Reich, M. Moros, A. Lewińska
Institutions: University of Rzeszów, University of Agriculture in Krakow, Universidad de Zaragoza, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Centro de Investigación Biomédica en Red, Instituto de Nanociencia y Materiales de Aragón
Language: English
Subfield: Physiology
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,340
OpenAlex ID: W4409117136
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