Major considerations of parenteral nutrological therapy in short bowel syndrome: a systematic review
Year: 2025
Type: review
Study design: Systematic Review
Abstract: Introduction: Short bowel syndrome (SBS) is a result of surgical resection or destruction of the bowel associated with the disease. Patients with SBS with intestinal failure (II) (SBS-II) experience decreased quality of life (QOL) and increased morbidity and mortality due to their dependence on parenteral support (PS). Patients treated with teduglutide have been able to reduce and even discontinue PS with varying degrees of success. Objective: To analyze the scientific evidence for teduglutide in parenteral support in patients with short bowel syndrome. Methods: The systematic review rules of the PRISMA Platform were followed. The search was conducted from August to October 2024 in the Web of Science, Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 91 articles were found. 29 articles were fully evaluated and 07 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 20 studies with a high risk of bias and 22 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=91.5%>50%. It was concluded that teduglutide can restore intestinal structural and functional integrity, promote mucosal growth, reduce gastric emptying and secretion, and increase nutrient absorption and enteral independence from parenteral nutrition. The 24-week treatment time with teduglutide was generally well tolerated in patients with short bowel syndrome with intestinal failure. The clinical studies showed that teduglutide treatment reduced the volumes and number of days of parenteral support for patients with short bowel syndrome with intestinal failure.
DOI: 10.54448/ijn25204
Authors: Ana Angélica Nogueira Lima, Marcelo Rodrigues Zacarkim, Firmino Lucas Barreto de Matos Nobre, Lara Maria Vilaça de Figueiredo, Erick Jorge de Souza Fernandes, José de Sousa Xavier, Alfredo Máximo Grilo Jardim, Carmen Melo do Vale, José George Brilhante Xavier, Arnaldo Costa de Medeiros Junior
Institution: Universidade Potiguar
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409123775