Work

Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part I: Synthesis of the Pyridazinyl Imidazolidinone Intermediate Enabled by Biocatalysis and CSTR Technologies

Year: 2025

Type: article

Source: Organic Process Research & Development

DOI: 10.1021/acs.oprd.5c00003

Authors: Qiang Yang, Yu Lu, Thomas J. Beauchamp, Kevin P. Cole, Jiang Wang, Srinivas Gangula, Silong Zhang, Zhaoshan Cui, Guopeng Wang, Lei Shi, Dajiang Jing, Fuliang Wei, Xuecheng Jiao, Xiang Li, Na Zhang, Xiangjun Jiang, Yulei Ma

Institutions: Eli Lilly (United States), Tianjin Economic-Technological Development Area

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: closed

OpenAlex ID: W4409140263

FWCI: 2.273

Cites: 50

Cited by: 10

Related to: 10