Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma
Year: 2025
Type: article
Abstract: Mugwort-allergic patients frequently experience severe respiratory allergies due to sensitization to the major allergen Art v 1, with allergen-specific immunotherapy (ASIT) as the only causal treatment to halt disease progression. This study evaluated the effects of subcutaneous (SCIT) and sublingual (SLIT) ASIT with purified recombinant Art v 1 (rArt v 1) in a murine model of mugwort pollen of asthma. BALB/c mice were sensitized with Artemisia vulgaris pollen extract and treated with either rArt v 1-based SCIT adjuvanted with Montanide ISA-51, rArt v 1-based SLIT, an extract-based commercial SLIT vaccine, or PBS. Both rArt v 1-based SCIT and SLIT improved lung pathology and reduced airway reactivity following allergen challenge, with rArt v 1-based SCIT inducing Th1-polarized immune responses marked by increased IFN-γ production and rArt v 1-specific IgG 1 /IgG 2a , while SLIT induced stronger mucosal IgA responses. These findings highlight the therapeutic potential of rArt v 1-based ASIT for mugwort allergy.
Source: npj Vaccines
Authors: Kairat Tabynov, Elmira Tailakova, Guliza Rakhmatullayeva, Turlan Bolatbekov, Yeow Hong Lim, Gleb Fomin, Meruert Babayeva, Rudolf Valenta, Kaissar Tabynov
Institutions: Kazakh National Agrarian Research University, JSC "Research Institute of Cardiology and Internal Diseases", Al-Farabi Kazakh National University, Universiti Malaysia Pahang Al-Sultan Abdullah, Sechenov University, Karl Landsteiner University of Health Sciences, Medical University of Vienna
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,890
Funder: Russian Science Foundation
Awards: G5323263512, G7045800928
OpenAlex ID: W4409147446