Work

Intrapleural pressure-controlled piezo-catalytic nanozyme for the inhibition of malignant pleural effusion

Year: 2025

Type: article

Abstract: Malignant pleural effusion is a challenge for cancer therapy. Here, the authors report on a piezoelectric nano-system that inhibits tumor growth in the thoracic cavity by piezo-generated reactive oxygen species using the intrapleural pressure, triggering immunogenic cell death, to treat malignant pleural effusion.

Source: Nature Communications

DOI: 10.1038/s41467-025-58354-9

Authors: Zihan Xu, Xiujing He, Yu Gui, Lingkai Tang, Yuxin Zhao, Linlin Song, Tianyue Xu, Meixu Chen, Yujie Zhao, Peixin Du, Xin Wang, Siyi Chen, Yong Luo, Feng Luo, Huan Meng, Jianping Hu, Wei Zhuo, Jing Jing, Hubing Shi

Institutions: Sichuan University, West China Hospital of Sichuan University, State Key Laboratory of Biotherapy, Chengdu University, Third People's Hospital of Chengdu, Southwest Jiaotong University, National Center for Nanoscience and Technology, Second Affiliated Hospital of Zhejiang University, Zhejiang University

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,990

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, National Key Research and Development Program of China, West China Hospital, Sichuan University

Awards: G1438714131, G1647910707, G4805079753, G7729668291

OpenAlex ID: W4409150797

FWCI: 4.667

Cites: 49

Cited by: 23

Related to: 10